As a Windows IT professional with years of experience managing Chrome deployments, I recommend using the Local Group Policy Editor for precise cookie control on specific websites. This method requires the Chrome Group Policy templates, available from chromeenterprise.google. Note: Group Policy is available on Windows Pro, Enterprise, or Education editions. If settings are locked, this bypasses restrictions without needing direct access to Chrome's menu.
Follow these proven steps to configure site-specific cookie permissions:
Restart Chrome or run gpupdate /force in Command Prompt for changes to take effect. Here's the detailed path visualization:
Computer Configuration > Administrative Templates > Google Chrome > Content settings
Key policies on the right:

This approach ensures enterprise-grade control, trusted by IT admins worldwide. For Registry alternatives, search Chrome Enterprise docs.